Association of MYH9 Polymorphisms with Hypertension in Patients with Chronic Kidney Disease in China

作者：Liu, Liping; Wang, Caili^*; Mi, Yan; Liu, Dan; Li, Li; Fan, Junying; Nan, Lei; Jia, Niya; Du, Yu

来源：Kidney & Blood Pressure Research, 2016, 41(6): 956-965.

DOI：10.1159/000452597

• Chronic kidney disease
• Hypertension
• MYH9
• Polymorphism
• Systolic blood pressure

Background/Aims:This study explored the correlation between hypertension and non-muscle myosin heavy chain 9 (MYH9) gene polymorphisms in Chinese chronic kidney disease (CKD) patients. Methods: This case-control study included 301 patients with CKD and 293 healthy controls. The El haplotype single nucleotide polymorphisms (SNPs) rs3752462 and rs4821480 were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. The association between MYH9 polymorphisms and high systolic blood pressure (SBP >= 140 mmHg) susceptibility in CKD patients was analysed. Results: The cases and controls had similar genotype and allele distributions at rs3752462 and rs4821480. No GG genotype at rs4821480 was observed. Patients with SBP < 140 mmHg were more likely to have the CC genotype (17.1%) than patients with SBP >= 140 mmHg (4.3%) (P = 0.001). Creatinine clearance (OR = 0.99, 95% CI = 0.98-0.10, P = 0.01) was associated with SBP in patients with CKD. The risk of SBP >= 140 mmHg was 0.24-fold greater among patients with the CC genotype than among patients with the TT genotype (P = 0.002). Conclusion: The rs3752462 polymorphism of MYH9 is associated with SBP in patients with CKD. The T allele in the dominant model was associated with an elevated risk for high SBP.

• 出版日期2016
• 单位内蒙古科技大学包头医学院