N-acetylcysteine fails to prevent renal dysfunction and oxidative stress after noniodine contrast media administration during percutaneous coronary interventions

作者：Buyukhatipoglu Hakan^*; Sezen Yusuf; Yildiz Ali; Bas Memduh; Kirhan Idris; Ulas Turgay; Turan Mehmet Nuri; Taskin Abdullah; Aksoy Nurten

来源：Polish Archives of Internal Medicine, 2010, 120(10): 383-389.

• N-acetylcysteine
• contrast nephropathy
• oxidative stress
• total antioxidant capacity
• total oxidant capacity

INTRODUCTION Oxidative stress is believed to have a role in contrast-induced nephropathy. Based on this assumption, several known antioxidants have been studied to assess their effect on nephropathy, especially N-acetylcysteine (NAC). However, its usefulness has yet to be confirmed.
OBJECTIVES We aimed to assess whether NAC has any protective effect on contrast-induced renal dysfunction, and whether NAC affects the parameters of oxidative stress in serum and urine.
PATIENTS AND METHODS Sixty patients with coronary artery disease, who were scheduled for percutaneous coronary intervention (PCI), were randomized into 2 groups: one group received 600 mg NAC intravenously and the other did not. Both groups were matched for age and gender. Before and 24 hours after the procedure, blood and urine samples were obtained to assess total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidative stress index (OSI), and renal function.
RESULTS Twenty-four hours after PCI, TOC and OSI levels were significantly increased and TAC levels significantly decreased, both in serum and urine. However, we did not observe any differences in oxidative parameters between patients who received NAC and those who did not. Multivariate analyses identified no protective effect of NAC on renal function, and no effect on oxidative parameters in either serum or urine.
CONCLUSIONS In this first clinical study that determined TOC and TAC levels in both serum and urine after exposure to contrast media, NAC was not found to affect oxidant parameters or protect against contrast nephropathy, at least in patients without the risk factors for nephropathy, such as diabetes mellitus or baseline renal or cardiac dysfunction.

• 出版日期2010-10