A highly sensitive near-infrared fluorescent probe for the detection of hydrogen sulfide and its application in living cells and mice

作者：Zhang, Xin; Sun, Runing; Duan, Guofeng; Zhou, Ziyan; Luo, Yanjun; Li, Wen; Zhang, Liying^*; Gu, Yueqing; Zha, Xiaoming^*

来源：New Journal of Chemistry, 2018, 42(24): 19795-19800.

DOI：10.1039/c8nj04824j

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Hydrogen sulfide (H2S), an endogenous gaseous signalling molecule, has attracted attention in biochemical research. The detection of H2S in living systems is essential for studying its functions. Although a variety of probes have been reported for the detection of cellular H2S, the development of rapid, highly selective and sensitive near-infrared (NIR) probes for in vivo detection of H2S still remains a challenging target. Herein we synthesized a near-infrared fluorescent probe Cy-PBA, with good selectivity, high sensitivity (limit of detection = 21 nM) and rapid response time (<1.5 minutes). Importantly, Cy-PBA was successfully applied for fluorescence imaging of H2S in living cells, mice and tissues with low cytotoxicity, indicating that it owns broad application prospects in the detection of H2S in biological samples.

• 出版日期2018-12-21
• 单位中国药科大学; 承德医学院