In vitro effects of fermented papaya (Carica papaya, L.) on platelets obtained from patients with type 2 diabetes

作者：Raffaelli F; Nanetti L; Montecchiani G; Borroni F; Salvolini E; Faloia E; Ferretti G; Mazzanti L^*; Vignini A

来源：Nutrition Metabolism and Cardiovascular Diseases, 2015, 25(2): 224-229.

DOI：10.1016/j.numecd.2014.10.013

• Diabetes
• Membrane fluidity
• Na+/K+-ATPase
• Oxidative stress
• Platelets

Background and aim: Oxidative stress is associated with insulin resistance pathogenesis, insulin secretion deficiency, and complication onset. Fermented papaya preparation (FPP), a dietary supplement obtained by fermentation of the papaya fruit, may be used as an antioxidant in the prevention of diabetic complications.
Methods and results: Platelets from 30 patients with type 2 diabetes mellitus (DM 2) and 15 healthy subjects were analyzed to evaluate the in vitro effects of FPP incubation. Na+/K+-adenosine triphosphatase (ATPase) activity, membrane fluidity, total antioxidant capacity (TAC), superoxide dismutase (SOD) activity, and conjugated diene levels were determined. In vitro FPP incubation improved platelet function, by enhancing Na+/K+-ATPase activity and membrane fluidity, and ameliorated the antioxidant system functionality, through an increase in TAC and SOD activity and a parallel decrease in conjugated diene levels in patients with DM 2.
Conclusion: Our data suggest that the incubation with FPP may have a protective effect on platelets from patients with DM 2, by preventing the progression of oxidative damage associated with diabetes and its complications.

• 出版日期2015-2