Pot, atom and step economic (PASE) synthesis of 5-monoalkylbarbiturates through domino aldol-Michael reaction

作者：Kalita Subarna Jyoti; Mecadon Hormi^*; Deka Dibakar Chandra

来源：Tetrahedron Letters, 2015, 56(5): 731-734.

DOI：10.1016/j.tetlet.2014.12.091

• 5-Monoalkylbarbiturates
• Sodium hydroxide
• PASE
• Domino reaction

A simple pot, atom and step economic (PASE) approach for the synthesis of 5-monoalkylbarbiturates by a one-pot reaction of barbituric acids, aldehydes, and ketones, involving a domino aldol-Michael reaction is described. The operational simplicity and cost effectiveness of this procedure makes it a sustainable strategy for the synthesis of 5-monoalkylbarbiturates.

• 出版日期2015-1-28