Monitoring of 2-deoxy-2[F-18]fluoro-D-glucose uptake in tumor-bearing mice using high-sensitivity projection imaging: compared with PET imaging

作者：Liao Mei Hsiu; Wey Shiaw Pyng; Jan Meei Ling; Chiang Chao Chih; Liao Tse Zung; Chi Chin Wen; Shen Lie Hang; Jan Tong Rong^*

来源：Nuclear Medicine Communications, 2010, 31(12): 1040-1044.

DOI：10.1097/MNM.0b013e3283406ab3

• chemotherapeutic
• efficacy
• high throughput
• screening
• microPET
• murine
• tumor
• model
• planar
• positron
• imaging system

Objective To investigate the feasibility of using high-sensitivity projection [F-18]fluoro-deoxyglucose imaging to monitor chemotherapeutic efficacy in BALB/c mice bearing CT-26 tumor implants
Methods A planar positron imaging system (PPIS) 4800 and a microPET R4 were used for projection and tomographic imaging, respectively Six disks filled with different volumes of F-18-FDG solution were scanned by PPIS for calibration check Tumor-bearing mice were treated with saline (control) or cyclophosphamide by intraperitoneal injections Tumor responses were evaluated by both PPIS and microPET imaging
Results The disk-activity ratios obtained from MS were 1 00 1 30 1 98 248 2 73 353 with corresponding volume ratios of 1 0 1 5 20 25 30 3 5 PPIS imaging in tumor-bearing mice showed that the tumor/non-tumor ratios were 1 62, 2 12, 3 03, 4 46, and 361 on days 7, 10, 13, 17, and 20, respectively, after tumor inoculation In addition, PPIS was used to monitor the chemotherapeutic effect of cyclophosphamide on tumor-bearing mice The correlation coefficients between the tumor sizes and tumor/non-tumor ratios for microPET and PPIS were 0 63 and 0 72, respectively, in the control group, and were 0 98 and 081, respectively, in the cyclophosphamide-treated group
Conclusion This study showed that PPIS imaging is a feasible modality for monitoring tumor responses These results suggest that PPIS, a potential high throughput screening imaging system, may be used for the prechnical evaluation of tumor response to new

• 出版日期2010-12
• 单位长春大学