Muscle versus Snail: Muscle wins

作者:Simoes Sergio; Tepass Ulrich*
来源:The Journal of Cell Biology, 2016, 212(2): 139-141.
DOI:10.1083/jcb.201512092

摘要

Epithelial-mesenchymal transitions (EMTs) are often governed by the transcription factor Snail and entail the loss of apical junctions from epithelial cells. In this issue, Weng and Wieschaus (2016. J Cell Biol. http://dx.doi.org/10.1083/jcb.201508056) report that actomyosin contractility can strengthen junctions to override Snail dependent junctional disassembly and postpone EMT during Drosophila melanogaster gastrulation.

  • 出版日期2016-1-18

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