Asymmetric aza-Michael addition: synthesis of (-)-allosedridine and (-)-2-epi-ethylnorlobelol

作者：Chen Li Ju; Hou Duen Ren^*

来源：Tetrahedron: Asymmetry , 2008, 19(6): 715-720.

DOI：10.1016/j.tetasy.2008.02.019

The combination of cross-metathesis and aza-Michael addition is an efficient method for generating piperidine alkaloids. Allosedridine and 2-epi-ethylnorlobelol were synthesized in six steps with ca. 25% overall yield. The aza-Michael addition is reversible for phenyl and alkyl ketones; however, the epimerization is not observed for the corresponding ester and amide.

• 出版日期2008-4-3
• 单位中央民族大学