Assembly of Quinoline, Triazole and Oxime Ether in a Single Molecular Entity: A Greener and One-pot Synthesis of Novel Oximes as Potential Cytotoxic Agents

作者：Praveena Koduru Sri Shanthi; Ramarao Edupuganti Veera Venkat Shivaji; Poornachandra Yedla; Kumar Chityal Ganesh; Babu Nallapati Suresh; Murthy Nandula Yadagiri Sreenivasa; Pal Sarbani^*

来源：Letters in Drug Design and Discovery, 2016, 13(3): 210-219.

DOI：10.2174/1570180812999150819095308

• Quinoline
• 1,2,3-triazole
• oxime
• cancer
• PDE4

An assembly of quinoline, triazole and oxime ether in a single molecular entity afforded a new template that has been used for the generation of a small library of molecules as potential cytotoxic agents. These molecules were synthesized successfully via a one pot multistep method using the copper(I)-catalyzed [3+2]-azide-alkyne cycloaddition (CuAAC) in water as the key step. All these compounds were synthesized in good to excellent yields and were screened for their inhibitory effects on the growth of four cancer cell lines in vitro. Some of these compounds showed encouraging cytotoxic effects against lung cancer cells and inhibition of PDE4 in vitro.

• 出版日期2016