The incidence of a first major osteoporotic fracture in Iceland and implications for FRAX

作者：Siggeirsdottir K^*; Aspelund T; Johansson H; Gudmundsson E F; Mogensen B; Jonsson B Y; Gudnason V; McCloskey E; Oden A; Sigurdsson G; Kanis J A

来源：Osteoporosis International, 2014, 25(10): 2445-2451.

DOI：10.1007/s00198-014-2777-3

• Fracture incidence
• FRAX
• Major osteoporotic fracture

Based on an extensive cohort study over 25 years, the present study supports the assumption that major osteoporotic fractures can be reasonably predicted from hip fracture rates. %26lt;br%26gt;The construct for FRAX models depends on algorithms to adjust for double counting of fracture outcomes in some models and in others, to estimate the incidence of a major fracture from hip fracture rates. The aim of the present study was to test the validity of these algorithms in a large prospective cohort. %26lt;br%26gt;The incidence of hip, clinical spine, distal forearm, and humerus fracture was determined in the prospective and ongoing population-based Reykjavik Study with follow up of 257,001 person-years. The incidence of a first major fracture was compared with the correction factors used in FRAX to adjust the incidence of several fracture outcomes for double counting. In addition, the incidence of a major osteoporotic fracture estimated from the Icelandic hip fracture rates was compared with the Malmo ratios used in FRAX. %26lt;br%26gt;The adjustments necessary to account for multiple fracture outcomes were similar to those previously derived from Sweden. Additionally, incidence of a first major osteoporotic fracture was similar to that derived for FRAX models. %26lt;br%26gt;The findings of the present study support the algorithms used in FRAX to estimate the incidence of a first major fracture and the predictive value of hip fracture for other major fractures.

• 出版日期2014-10
• 单位河北医科大学