Asymmetric Hetero-Diels-Alder Reaction of Danishefsky%26apos;s Dienes with alpha-Carbonyl Esters Catalyzed by an Indium(III)-PyBox Complex

作者：Zhao Bei; Loh Teck Peng^*

来源：Organic Letters, 2013, 15(12): 2914-2917.

DOI：10.1021/ol400841s

An efficient catalytic enantioselective hetero-Diels-Alder reaction of Danishefsky%26apos;s dienes with alpha-carbonyl esters using a chiral In(III)-pybox complex has been demonstrated. This protocol offers several advantages, including mild reaction conditions, relatively low catalyst loading, and good to excellent enantioselectivities. Furthermore, the absolute configurations of the new alkynyl-containing products were determined by CD spectra in combination with TD-DFT calculations.

• 出版日期2013-6-21
• 单位南阳理工学院; 苏州大学