Antineoplastic agents 596. Isolation and structure of chromomycin A(5) from a Beaufort Sea microorganism

作者：Pettit George R^*; Tan Rui; Pettit Robin K; Doubek Dennis L; Chapuis Jean Charles; Weber Christine A

来源：RSC Advances, 2015, 5(12): 9116-9122.

DOI：10.1039/c4ra16517a

A microorganismidentified as Streptomyces sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D NMR spectral analyses) of a diastereomer of chromomycin A2 (2) designated chromomycin A(5) (5). Chromomycin A(5) displayed very potent cancer cell growth inhibitory activity (reaching with MCF-7 breast cancer GI(50) 0.00073 mg mL(-1)) against a mini-panel of murine and human cancer cell lines.

• 出版日期2015