Asymmetric Addition of 3-Thienyl Aluminum to Ketones Catalyzed by the Simple Titanium Catalytic System of (S)-1,1 '-Binaphthol

作者：Ge Min; Zhang Lijun^*; Tu Bing; Zhou Shuangliu^*

来源：Chinese Journal of Organic Chemistry, 2018, 38(3): 672-676.

DOI：10.6023/cjoc201710004

• asymmetric synthesis
• thienyl
• aluminum
• titanium
• ketones

The optically active diaryl alcohols bearing thienyl group are well-known for their biological activity as well as key substructure in bioactive compounds and pharmaceuticals. The asymmetric addition of 3-thienylaluminum to ketones afforded the optically active 3-thienyl arylethanols in good yields with high enantioselectivities of up to 910% ee employing the simple titanium catalytic system of (S)-1, 1'-binaphthol. The catalytic system could also suit for various ketones bearing an electron-donating or electron-withdrawing groups to afford the corresponding diarylethanols containing substituted 3-thienyl groups.

• 出版日期2018-3-25
• 单位安徽师范大学