A Lower Baseline CD4/CD8 T-Cell Ratio Is Independently Associated with Immunodiscordant Response to Antiretroviral Therapy in HIV-Infected Subjects

作者：Rosado Sanchez I; Herrero Fernandez I; Alvarez Rios A I; Genebat M; Abad Carrillo M A; Ruiz Mateos E; Pulido F; Gonzalez Garcia J; Montero M; Bernal Morell E; Vidal F; Leal M; Pacheco Y M^*

来源：Antimicrobial Agents and Chemotherapy, 2017, 61(8): e00605- 17.

DOI：10.1128/AAC.00605-17

• CD4/CD8 T-cell ratio
• delayed cART
• low CD4 recovery
• T-cell turnover
• thymic function
• CD4/CD8 ratio
• antiretroviral therapy
• human immunodeficiency virus
• immunodiscordant

We explored if baseline CD4/CD8 T-cell ratio is associated with immunodiscordant response to antiretroviral therapy in HIV-infected subjects. Comparing immunodiscordant and immunoconcordant subjects matched by pretreatment CD4 counts, we observed a lower pretreatment CD4/CD8 T-cell ratio in immunodiscordant subjects. Furthermore, pretreatment CD4/CD8 T-cell ratio, but not CD4 counts, correlated with the main immunological alterations observed in immunodiscordants, including increased regulatory T-cell (Treg) frequency and T-cell turnover-related markers. Then, in a larger cohort, only baseline CD4/CD8 T-cell ratio was independently associated with immunodiscordance, after adjusting by the viral CXCR4-tropic HIV variants. Our results suggest that the CD4/CD8 T-cell ratio could be an accurate biomarker of the subjacent immunological damage triggering immunodiscordance.

• 出版日期2017-8