Toll-like receptor 4 polymorphisms to determine acute pancreatitis susceptibility and severity: A meta-analysis

作者：Zhou, Xiao-Jin; Cui, Yan; Cai, Li-Yi; Xiang, Jing-Ying; Zhang, Yan^*

来源：World Journal of Gastroenterology, 2014, 20(21): 6666-6670.

DOI：10.3748/wjg.v20.i21.6666

• Toll-like receptor 4
• Acute pancreatitis
• Risk
• Single nucleotide polymorphisms

AIM: To investigate the correlation of toll-like receptor 4 (TLR4) gene Asp299Gly and Thr399Ile polymorphisms and acute pancreatitis (AP) risk and severity.
METHODS: To get a more precise estimation of the relationship, a comprehensive search was performed to examine all the eligible studies of TLR4 Asp299Gly and Thr399Ile polymorphisms and AP risk. The odds ratios with 95% confidence intervals were used to assess the strength of the association. Publication bias was analyzed by Begg's funnel plots.
RESULTS: In total, six studies with 1255 cases and 998 controls were included in this meta-analysis. Totally, no significant associations were found between TLR4 Asp299Gly or Thr399Ile polymorphisms and AP risk using five models with high homogeneity (P > 0.05). Furthermore, stratification analysis by ethnicity or assay also found no significant association in these two polymorphisms (P > 0.05), and TLR4 Asp299Gly was not associated with AP severity (P > 0.05). In addition, no publication bias was found in these studies (P > 0.05).
CONCLUSION: Our current meta-analysis suggests that TLR4 Asp299Gly and Thr399Ile polymorphisms may not be risk factors to AP susceptibility.

• 出版日期2014-6-7
• 单位苏州大学; 南京医科大学