A Prob(e)able Route to Lysine Acylation

作者:Wagner Gregory R; Hirschey Matthew D*
来源:Cell Chemical Biology, 2017, 24(2): 126-128.
DOI:10.1016/j.chembiol.2017.01.011

摘要

Non-enzymatic modification of proteins by acyl-CoA species involved in intermediary metabolism is a possible explanation for widespread protein acylation. In this issue, Kulkarni et al. (2017) develop a set of chemoproteomic probes to interrogate the role of malonyl-CoA in mediating protein malonylation and find malonylation influences glycolysis in cancer cells.

  • 出版日期2017-2-16