Amino acid chirons: a tool for asymmetric synthesis of heterocycles

作者：Singh Priyanka; Samanta Krishnananda; Das Sanjit Kumar; Panda Gautam^*

来源：Organic and Biomolecular Chemistry, 2014, 12(33): 6297-6339.

DOI：10.1039/c4ob00943f

As a result of their easy availability in enantiomerically enriched form and their possession of synthetically transformable diverse functional groups, amino acids have been extensively used by synthetic organic and medicinal chemists as a chiral pool for access to heterocycles (monocycles, bicycles or polycycles, either bridged or fused). This review describes the syntheses of diverse asymmetric heterocycles with various membered rings (n = 3-9) followed by benzo or heteroannulated ones, for the period from 1996 to Dec. 2013. It details solution phase synthetic methodologies in which the naturally occurring alpha-amino acid is incorporated, totally or partially, into the final product.

• 出版日期2014