Association between Helicobacter pylori Infection and Laryngeal Squamous Cell Carcinoma in a Chinese Male Population

作者：Shi, Yi; Gong, Hongli; Zhou, Liang^*; Tao, Lei; Shi, Yong; Cao, Wenjun; Cheng, Lei

来源：ORL-Journal for Oto-Rhino-Laryngology Head and Neck Surgery, 2011, 73(6): 295-300.

DOI：10.1159/000330955

• Laryngeal squamous cell carcinoma
• Helicobacter pylori
• Nested polymerase chain reaction
• Sequence analyses

Objectives: To investigate the presence of Helicobacter pylori in the larynx, and to identify the relationship between H. pylori infection and laryngeal squamous cell carcinoma in a male population. Methods: This study included 59 male patients with laryngeal squamous cell carcinoma and 41 control subjects. Nested polymerase chain reaction and target fragment sequencing were used to detect the presence of H. pylori in laryngeal mucosa. Logistic regression analysis was used to assess the association between H. pylori infection and laryngeal cancer. Results: H. pylori was present in a significantly greater number of patients with laryngeal carcinoma (76.3%) than in control subjects (31.7%) (p < 0.001). The correlation between H. pylori infection and laryngeal cancer was highly significant (OR = 9.82, 95% CI [3.35, 28.80], p < 0.001). Conclusions: The present study shows that H. pylori is present in the laryngeal mucosa of men, and supports a possible relationship between H. pylori infection and laryngeal squamous cell carcinoma in a male population.

• 出版日期2011
• 单位复旦大学