Nanostructured Systems Containing Rutin: In Vitro Antioxidant Activity and Photostability Studies

作者：Almeida Juliana S; Lima Fernanda; Da Ros Simoni; Bulhoes Luis O S; de Carvalho Leandro M; Beck Ruy C R^*

来源：Nanoscale Research Letters, 2010, 5(10): 1603-1610.

DOI：10.1007/s11671-010-9683-1

• Antioxidant activity
• Nanocapsules
• Nanoemulsions
• Nanoparticles
• Photostability
• Rutin

The improvement of the rutin photostability and its prolonged in vitro antioxidant activity were studied by means of its association with nanostructured aqueous dispersions. Rutin-loaded nanocapsules and rutin-loaded nanoemulsion showed mean particle size of 124.30 +/- A 2.06 and 124.17 +/- A 1.79, respectively, polydispersity index below 0.20, negative zeta potential, and encapsulation efficiency close to 100%. The in vitro antioxidant activity was evaluated by the formation of free radical center dot OH after the exposure of hydrogen peroxide to a UV irradiation system. Rutin-loaded nanostructures showed lower rutin decay rates [(6.1 +/- A 0.6) 10(-3) and (5.1 +/- A 0.4) 10(-3) for nanocapsules and nanoemulsion, respectively] compared to the ethanolic solution [(35.0 +/- A 3.7) 10(-3) min(-1)] and exposed solution [(40.1 +/- A 1.7) 10(-3) min(-1)] as well as compared to exposed nanostructured dispersions [(19.5 +/- A 0.5) 10(-3) and (26.6 +/- A 2.6) 10(-3), for nanocapsules and nanoemulsion, respectively]. The presence of the polymeric layer in nanocapsules was fundamental to obtain a prolonged antioxidant activity, even if the mathematical modeling of the in vitro release profiles showed high adsorption of rutin to the particle/droplet surface for both formulations. Rutin-loaded nanostructures represent alternatives to the development of innovative nanomedicines.

• 出版日期2010-10