No detection of human bocavirus in amniotic fluid samples from fetuses with hydrops or isolated effusions

作者：Enders Martin^*; Lindner Juha; Wenzel Juergen J; Baisch Carola; Schalasta Gunnar; Enders Gisela; Modrow Susanne

来源：Journal of Clinical Virology, 2009, 45(4): 300-303.

DOI：10.1016/j.jcv.2009.04.005

• Human bocavirus
• Parvovirus B19
• Pregnancy
• Hydrops
• Fetus

Background: Human bocavirus (HBoV) is a recently identified parvovirus associated with respiratory disease in infants. Animal bocaviruses have been shown to cause intrauterine infection, fetal anasarca and abortion in late gestation.
Objectives: To investigate whether HBoV infection is associated with fetal hydrops, fetal anemia or isolated fetal effusions. Study design: We determined the prevalence of HBoV and parvovirus B19 (B19) DNA in amniotic fluid samples from fetuses with hydrops, anemia or isolated effusions using different real-time PCR protocols, and the HBoV IgG and IgM positivity rate in pregnant women with fetal hydrops or normal ultrasound findings by a non-commercial virus-like particle-based enzyme immunoassay.
Results: None of 87 amniotic fluid samples tested was HBoV DNA positive. Twelve of 60 fetuses with hydrops or anemia were found B19 DNA positive. Anti-HBoV IgG antibodies were detected in 100% (19/19) and 94% (47/50) of serum samples from pregnant women with fetal hydrops and normal ultrasound findings, respectively. All serum samples were found negative for anti-HBoV IgM.
Conclusion: We suggest that HBoV is not a common cause of fetal hydrops, anemia or isolated effusions. This has to be confirmed by further studies of proven gestational HBoV infection.

• 出版日期2009-8
• 单位河北医科大学