Association of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathy

作者：Zhong, Weiqiang; Huang, Zhongliang; Wu, Yong; Jiang, Zongpei^*; Zhou, Tian-Biao

来源：Journal of the Renin-Angiotensin-Aldosterone System, 2015, 16(3): 660-665.

DOI：10.1177/1470320314524011

• IgA nephropathy
• aldosterone synthase
• CYP11B2
• gene polymorphism
• meta-analysis

Objective: This meta-analysis was conducted to assess the association of aldosterone synthase (CYP11B2) gene polymorphism with the risk of immunoglobulin A (IgA) nephropathy (IgAN) and the progression of IgAN.
Methods: The literature on associations was identified from PubMed and the Cochrane Library on 1 October 2013, and eligible reports were synthesized.
Results: Eligible reports were recruited into this meta-analysis for the association of CYP11B2-344C/T (rs1799998) gene polymorphism with IgAN risk, and the progression of IgAN. In this meta-analysis, the association of CYP11B2-344C/T (rs1799998) gene polymorphism with IgAN risk was not found in overall populations and in Asians. Interestingly, the C allele and CC genotype were associated with the risk of IgAN in Caucasians, but the TT genotype was not.
Conclusion:CYP11B2-344C/T gene polymorphism is not associated with IgAN risk and IgAN progression in overall populations and in Asians, but CYP11B2 C allele and CC genotype were associated with the risk of IgAN in Caucasians. However, more studies should be performed in the future to confirm this association.

• 出版日期2015-9
• 单位惠州市中心人民医院; 中山大学