An Efficient Route to 1-Vinylpyrrole-2-carbaldehydes

作者：Mikhaleva Al'bina I^*; Ivanov Andrey V; Skital'tseva Elena V; Ushakov Igor' A; Vasil'tsov Alexander M; Trofimov Boris A

来源：Synthesis (Germany), 2009, 2009(4): 587-590.

DOI：10.1055/s-0028-1083312

• aldehydes
• pyrroles
• formylation
• oxalyl chloride
• Vilsmeier-Haack reaction

1-Vinylpyrroles are formylated by the N,N-dimethyl-formamide/oxalyl chloride reagent system (CH(2)Cl(2), r.t., 40 min) to give the corresponding 1-vinylpyrrole-2-carbaldehydes in yields up to 97%.