American Ginseng Extract (Panax quinquefolius L.) Is Safe in Long-Term Use in Type 2 Diabetic Patients

作者：Mucalo Iva^*; Jovanovski Elena; Vuksan Vladimir; Bozikov Velimir; Romic Zeljko; Rahelic Dario

来源：Evidence-Based Complementary and Alternative Medicine, 2014, 2014: 969168.

DOI：10.1155/2014/969168

Aim. The objective of the present study was to test the safety of supplementation with the American ginseng (AG) interventional material as an adjunct to conventional therapy (diet and/or medications) in type 2 diabetes, using a double-blind, randomized, placebo-controlled, parallel design. Methods. Each participant received either AG (10% ginsenosides) or placebo capsules (500mg/meal = 3 g/day) for a period of 12 weeks. Outcomes included measures of safety including kidney urates and creatinine), liver AST and ALT), and haemostatic PV and INR). Results. Seventy-four participants with well-controlled type 2 diabetes (sex: 28M and 46 F, age: 63 +/- 9.5, BMI: 32 +/- 5, and HbA1c: 7 +/- 1.3), randomized to either intervention (n = 35) or control (n = 39) group, completed the study. There was no change in any of the measures of safety between treatments from baseline. The number or severity of adverse events did not differ between the AG intervention and placebo. Conclusion. Following 12 weeks of supplementation with AG, safety was not compromised in a high cardiovascular disease (CVD) risk population of patients with type 2 diabetes. This demonstrated that safety is noteworthy, as reviews have continuously warned of possible adverse effects of ginseng consumption.

• 出版日期2014