A potential anticancer ability of 1,2-di(quinazolin-4-yl) diselane against gastric cancer cells through ROS signaling pathway

作者：Wei, Jun; Yang, Yong; Wang, Zhixiang; Wang, Zijian; Fu, Changlai; Zhu, Jianqing; Shan, Jiping; Huang, Yingjiu; Tang, Bikui^*; Jiang, Danbin^*

来源：Medicinal Chemistry Research, 2017, 26(4): 841-848.

DOI：10.1007/s00044-017-1799-8

• Gastric cancer
• 1,2-di(quinazolin-4-yl)diselane
• Anticancer
• ROS pathway

Gastric cancer is the third most lethal malignancy worldwide. Most gastric cancer patient are discovered at a late or advanced stage, which needed systemic chemotherapy regiments. In this study, we aim to investigate the antitumor activity and mechanisms of 1, 2-di(quinazolin-4-yl)diselane (LG003) against gastric cancer cells. The cell viability, inhibition, apoptosis, DNA damage and ROS levels of gastric cancer cells were measured after treatment with LG003. We identifies anticancer activity of LG003 on gastric cancer and the potential molecular mechanisms. LG003 significantly inhibited cell viability and changed the morphology of gastric cancer cells. Moreover, LG003 induced cell apoptosis and DNA damage via ROS signaling pathway. These results indicates that 1,2di(quinazolin-4-yl) diselane (LG003) is a antitumor drug candidate that has great potential as a promising agent for therapy in gastric cancer.

• 出版日期2017-4
• 单位东南大学; 蚌埠医学院