A short synthetic route towards merosesquiterpenes with a benzoxanthene skeleton

作者：Fernandez Antonio; Alvarez Esteban; Alvarez Manzaneda Ramon; Chahboun Rachid^*; Alvarez Manzaneda Enrique

来源：Chemical communications, 2014, 50(86): 13100-13102.

DOI：10.1039/c4cc05116e

A short synthetic sequence for the preparation of merosesquiterpenes with a benzoxanthene skeleton starting from commercial (-)-sclareol is reported. The D ring of the target compound is obtained through a Diels-Alder cycloaddition, involving a dienoldiether derived from a tricyclic alpha, beta-enone synthesized in two steps from the starting diterpene. Utilizing this procedure, the preparation of (+)-hongoquercin A and the first synthesis of (+)-cyclospongiaquinone-1 were achieved.

• 出版日期2014