Antimicrobial Drug Resistance Trends of Bacteremia Isolates in a Rural Hospital in Southern Mozambique

作者：Mandomando Inacio^*; Sigauque Betuel; Morais Luis; Espasa Mateu; Valles Xavier; Sacarlal Jahit; Macete Eusebio; Aide Pedro; Quinto Llorenc; Nhampossa Tacilta; Machevo Sonia; Bassat Quique; Menendez Clara; Ruiz Joaquim; Roca Anna; Alonso Pedro L

来源：The American Journal of Tropical Medicine and Hygiene, 2010, 83(1): 152-157.

DOI：10.4269/ajtmh.2010.09-0578

Antibiotic resistance in Africa is increasing but insufficiently recognized as a public health problem. However, there are scarce data for antimicrobial resistance trends among bloodstream isolates in sub-Saharan Africa. Antimicrobial drug resistance trends among bacteria isolated from blood of children <15 years of age admitted to the Manhica District Hospital in Mozambique during May 2001 April 2006 were monitored by disk diffusion. We documented a linear trend of increasing resistance throughout the study period to chloramphenicol among isolates of Non-typhi Salmonella (P < 0.001), Escherichia coli (P = 0.002), Staphylococcus aureus (P < 0.001), and Haemophilus influenzae (P < 0.001). Increasing resistance to ampicillin was also observed for H. influenzae isolates (P < 0.001). We report trends of increasing resistance among the most frequent etiologies of bacteremia to the most commonly used antibiotics for empirical therapy in this community. Quinolones and third-generation cephalosporines may be needed in the short term to manage community-acquired infections.

• 出版日期2010-7