Unexpected Photo-instability of 2,6-Sulfonamide-Substituted BODIPYs and Its Application to Caged GABA

作者:Takeda Aoi; Komatsu Toru; Nomura Hiroshi; Naka Masamitsu; Matsuki Norio; Ikegaya Yuji; Terai Takuya; Ueno Tasuku; Hanaoka Kenjiro; Nagano Tetsuo; Urano Yasuteru
来源:ChemBioChem, 2016, 17(13): 1233-1240.
DOI:10.1002/cbic.201600097

摘要

Investigation of the unexpected photo-instability of 2,6-sulfonamide-substituted derivatives of the boron dipyrromethene (BODIPY) fluorophore led to the discovery of a photoreaction accompanied by multiple bond scissions. We characterized the photoproducts and utilized the photoreaction to design a caged -aminobutyric acid (GABA) derivative that can release GABA upon irradiation in the visible range (>450nm). This allowed us to stimulate neural cells in mouse brain slices.

  • 出版日期2016-7-1