Alterations in neurofilaments and the transformation of the cytoskeleton in axons may provide insight into the aberrant neuronal changes of Alzheimer's disease

作者：Vickers J C^*; Kirkcaldie M T; Phipps A; King A E

来源：Brain Research Bulletin, 2016, 126: 324-333.

DOI：10.1016/j.brainresbull.2016.07.012

• Neurofilament
• Alzheimer's disease
• Axon
• Plaque
• Dystrophic
• Tau

Neurofilaments are major protein constituents of the brain, but are particularly abundant in specific subpopulations of neurons and likely have a key role in the regulation of axonal calibre. Neurofilament proteins may also be involved in the transformation of the neuronal cytoskeleton leading to substantial tau pathology in axons damaged by A beta, subsequently leading to neurofibrillary pathology in their cell bodies of origin. An understanding of neurofilamentous changes in axons and subsequent tau pathology may provide insight into how A beta pathology may stimulate an aberrant plasticity-related response of damaged neurons, leading to the progressive and degenerative changes in the neuronal cytoskeleton that result in synapse loss and neuronal degeneration.

• 出版日期2016-9