-1154G/A and-2578C/A polymorphisms of the vascular endothelial growth factor gene in Tunisian Alzheimer patients in relation to beta-amyloid (1-42) and total tau protein

作者：Smach Mohamed Ali^*; Charfeddine Bassem; Ben Othman Leila; Lammouchi Turkia; Ltaief Afef; Nafati Souhir; Dridi Hedi; Bennamou Soufien; Limem Khalifa

来源：Neuroscience Letters, 2010, 472(2): 139-142.

DOI：10.1016/j.neulet.2010.01.073

• Vascular endothelial growth factor (VEGF)
• Polymorphisms
• Alzheimer's disease (AD)
• t-tau
• beta-Amyloid

Recent evidences indicate that polymorphisms within the promoter region of the vascular endothelial growth factor (VEGF) gene may elevate the risk for Alzheimer's disease (AD). To further investigate, we have analyzed association between promoter polymorphisms of the VEGF gene in 93 AD patients and age and sex matched 113 controls from Tunisian population. The distribution of genotype and allele frequencies of the VEGF (-2578C/A) and (-1154G/A) polymorphisms did not differ significantly between AD and control groups (p > 0.05). In the subgroup of ApoE epsilon 4 carriers, the -2578A was observed to be significantly higher in the AD patients than in the control individuals. After adjusting the data by gender, age and the ApoE e4 status using logistic regression, the -2578A allele was found to increase the risk for sporadic AD by 1.7-fold. The present study provides the evidence that the -2578A allele may be associated with the development of AD in the individuals with ApoE epsilon 4 allele. In addition, AD patients carrying the -2578A allele had lower A beta 42 (p = 0.029) levels than those without this allele, particularly in subjects with ApoE epsilon 4 allele.

• 出版日期2010-3-19