Comparative In Vitro Analysis of Dissolution Profiles of Furosemide Tablets Marketed in Bahia, Brazil

作者：Ferreira Matheus da S; Viana Larissa C M G; Matos Rafael A; Sa Ramon R; Silva Fernanda A dos S; Mota Millen D; Cazedey Edith C L; Magalhaes Hemerson I F; Santos Junior Anibal de F

来源：Latin American Journal of Pharmacy, 2016, 35(9): 2064-2070.

• dissolution profiles
• furosemide tablets
• in vitro analysis

Furosemide is a diuretic used in the treatment of hypertensive, edemas and other clinical conditions. The aim of this study was to compare the dissolution profiles of 40 mg tablets of furosemide available as the reference drug (R), generic (G) and similar (S) commercialized in Bahia, Brazil using a simple, fast and low cost ultraviolet spectrophotometric method. The tests were performed in compliance with the Brazilian Pharmacopoeia (5th ed.) and United States Pharmacopeia 34th. The proposed methodology for quantifying the drug was validated presenting precision, linearity and accuracy. The product R, G and S showed dissolution efficiency of the 97.9, 90.9 and 95.2 %, respectively. The calculation of f2 factor lost its discriminative power because the formulations studied showed dissolution of 85 % off drug, in less than 15 min. However, all the products released furosemide satisfactorily, with at least 80% of the drug dissolved within 30 min.

• 出版日期2016-11