A Faster cDNA Microarray Gene Expression Data Classifier for Diagnosing Diseases

作者：Hsieh Sun Yuan^*; Chou Yu Chun^*

来源：IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2016, 13(1): 43-54.

DOI：10.1109/TCBB.2015.2474389

• Bioinformatics
• classification
• gene-expression graph (GEG)
• GEG-based classifier
• microarray

Profiling cancer molecules has several advantages; however, using microarray technology in routine clinical diagnostics is challenging for physicians. The classification of microarray data has two main limitations: 1) the data set is unreliable for building classifiers; and 2) the classifiers exhibit poor performance. Current microarray classification algorithms typically yield a high rate of false-positives cases, which is unacceptable in diagnostic applications. Numerous algorithms have been developed to detect false-positive cases; however, they require a considerable computation time. To address this problem, this study enhanced a previously proposed gene expression graph (GEG)-based classifier to shorten the computation time. The modified classifier filters genes by using an edge weight to determine their significance, thereby facilitating accurate comparison and classification. This study experimentally compared the proposed classifier with a GEG-based classifier by using real data and benchmark tests. The results show that the proposed classifier is faster at detecting false-positives.

• 出版日期2016-2
• 单位河北医科大学