alpha-Synuclein gene duplication impairs reward learning

作者：Keri Szabolcs^*; Moustafa Ahmed A; Myers Catherine E; Benedek Gyoergy; Gluck Mark A

来源：Proceedings of the National Academy of Sciences, 2010, 107(36): 15992-15994.

DOI：10.1073/pnas.1006068107

• Parkinson disease
• reinforcement learning
• dopamine
• basal ganglia

alpha-Synuclein (SNCA) plays an important role in the regulation of dopaminergic neurotransmission and neurodegeneration in Parkinson disease. We investigated reward and punishment learning in asymptomatic carriers of a rare SNCA gene duplication who were healthy siblings of patients with Parkinson disease. Results revealed that healthy SNCA duplication carriers displayed impaired reward and intact punishment learning compared with noncarriers. These results demonstrate that a copy number variation of the SNCA gene is associated with selective impairments on reinforcement learning in asymptomatic carriers without the motor symptoms of Parkinson disease.

• 出版日期2010-9-7