A biocatalytic approach for regioselective monoacetylation of 3-aryloxy-1,2-propanediols by porcine pancreatic lipase

作者：Meena Vachan Singh; Banerjee U C^*

来源：Monatshefte fur Chemie, 2012, 143(6): 951-953.

DOI：10.1007/s00706-011-0688-y

• Lipases
• Monoacetylation
• Regioselectivity
• 3-Aryloxy-1,2-propanediol
• Biocatalysis

Among the various lipases screened for the regioselective monoacetylation of 3-aryloxy-1,2-propanediols, porcine pancreatic lipase was found to afford a higher yield. The selectivity for the monoacetylation process was maximized by using different organic solvents and diisopropyl ether gave the highest conversion to monoacetylated product (ca. 98%). The optimized reaction afforded excellent yields of the monoacetylated product with regioselectivity at the terminal hydroxyl group in the presence of various aryl substituents in the starting material.

• 出版日期2012-6