A Spiking Neural Network Methodology and System for Learning and Comparative Analysis of EEG Data From Healthy Versus Addiction Treated Versus Addiction Not Treated Subjects

作者：Doborjeh Maryam Gholami^*; Wang Grace Y; Kasabov Nikola K; Kydd Robert; Russell Bruce

来源：IEEE Transactions on Biomedical Engineering, 2016, 63(9): 1830-1841.

DOI：10.1109/TBME.2015.2503400

• Electroencephalography (EEG) comparative analysis
• EEG data
• EEG data classification
• evolving spiking neural networks (eSNNs)
• GO/NOGO tasks
• methadone maintenance treatment (MMT)
• NeuCube
• opiate addicts
• spatiotemporal brain data (STBD)

This paper introduces a method utilizing spiking neural networks (SNN) for learning, classification, and comparative analysis of brain data. As a case study, the method was applied to electroencephalography (EEG) data collected during a GO/NOGO cognitive task performed by untreated opiate addicts, those undergoing methadone maintenance treatment (MMT) for opiate dependence and a healthy control group. Methods: the method is based on an SNN architecture called NeuCube, trained on spatiotemporal EEG data. Objective: NeuCube was used to classify EEG data across subject groups and across GO versus NOGO trials, but also facilitated a deeper comparative analysis of the dynamic brain processes. Results: This analysis results in a better understanding of human brain functioning across subject groups when performing a cognitive task. In terms of the EEG data classification, a NeuCube model obtained better results (the maximum obtained accuracy: 90.91%) when compared with traditional statistical and artificial intelligence methods (the maximum obtained accuracy: 50.55%). Significance: more importantly, new information about the effects of MMT on cognitive brain functions is revealed through the analysis of the SNN model connectivity and its dynamics. Conclusion: this paper presented a new method for EEG data modeling and revealed new knowledge on brain functions associated with mental activity which is different from the brain activity observed in a resting state of the same subjects.

• 出版日期2016-9