Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid

作者：Vukelic Marija D^*; Mitic Zarko J; Miljkovic Miroslav S; Zivkovic Jelena M; Ignjatovic Nenad L; Uskokovic Dragan P; Zivanov Curlis Jelena Z; Vasiljevic Perica J; Najman Stevo J

来源：Journal of Applied Biomaterials & Functional Materials, 2012, 10(1): 43-48.

DOI：10.5301/JABFM.2012.9274

• EDS
• IR spectroscopy
• Nanomaterial
• N-CP/PLGA
• SEM

Simulated body fluid (SBF) is an artificial fluid which has ionic composition and ionic concentration similar to human blood plasma.
Purpose: This paper compares the interaction between the nanomaterial containing calcium phosphate/poly-DL-lactide-co-glycolide (N-CP/PLGA) and SBF, in order to investigate whether and to what extent inorganic ionic composition of human blood plasma leads to the aforementioned changes in the material.
Methods: N-CP/PLGA was incubated for 1, 2, 3, and 5 weeks in SBF. The surface of the material was analyzed on SEM-EDS and FTIR spectrometer, while SBF was subjected to pH and electrical conductivity measurement.
Results: Our results indicate that dissolution of the polymer component of the material N-CP/PLGA and precipitation of the material similar to hydroxyapatite on its surface are based on the morphologic changes seen in this material.
Conclusions: The mechanism of the apatite formation on the bioceramic surface was intensively studied and was considered crucial in designing the new biomaterials. The results obtained in this work indicate that N-CP/PLGA may be a good candidate for application to bone regeneration.

• 出版日期2012