Asymmetric alpha-Amination of Aldehydes and Ketones Catalyzed by tert-Butoxy-L-Proline

作者：Ait Youcef Ramzi; Kalch Delphine; Moreau Xavier; Thomassigny Christine; Greck Christine^*

来源：Letters in Organic Chemistry, 2009, 6(5): 377-380.

DOI：10.2174/157017809788681293

• Electrophilic amination
• organocatalysis
• tert-butoxyproline
• azodicarboxylate
• alpha-hydrazinoalcohol

Asymmetric electrophilic alpha-amination of aldehydes and ketones is described using trans-3-tert-butoxy-L-proline and trans-4-tert-butoxy-L-proline as efficient catalysts. Good yields and high enantioselectivities are obtained working at 0 degrees C or at room temperature with a catalyst loading of only 5 mol%.

• 出版日期2009-7