An Association Study Identifies Two Single Nucleotide Polymorphisms on Chromosome 11q23.3 as a Risk Locus for Acute Myocardial Infarction in the Chinese Han Population

作者：Shen Botao; Zhao Wei; Zheng Yang^*; Chen Xiaohui; Xu Weihong; Li Shibo

来源：Clinical Laboratory, 2015, 61(11): 1609-1616.

DOI：10.7754/Clin.Lab.2015.150331

• myocardial infarction
• genetics
• ethnicity
• Chinese
• single nucleotide polymorphisms
• coronary artery disease

Background: To evaluate whether the Chinese Han population harbors genetic markers associated with risk of acute myocardial infarction (MI), which have previously been identified in other ethnic populations.
Methods: According to predefined criteria, 549 Chinese patients with acute MI and 551 Chinese subjects (controls) without a history of coronary artery disease (CAD) were selected for the study. Three prevalent single nucleotide polymorphisms (SNPs; rs1412444(LIPA), rs662799(APOA5) and rs964184(ZNF259)) associated with CAD and MI in other ethnic populations, were selected for sequence and association analyses within blood DNA of the Chinese Han population.
Results: Only two SNPs, rs662799 (AP0A5) and rs964184 (ZNF259) found at two independent loci, were associated with risk of MI in the Chinese Han population. Using Bonferroni correction methods, significant differences in the association of these two SNPs (rs662799 (p = 0.0228) and rs964184 (p = 0.0060)) between Chinese patients with MI versus controls were revealed.
Conclusions: We identified a significant association between two SNPs (rs964184 and rs662799) on chromosome 11q23.3 and MI risk in the Chinese Han population, which extends their clinical relevance to predicting the risk of MI in diverse ethnic populations.

• 出版日期2015
• 单位吉林大学