A common origin of synaptic vesicles undergoing evoked and spontaneous fusion

作者：Hua Yunfeng; Sinha Raunak; Martineau Magalie; Kahms Martin; Klingauf Juergen^*

来源：Nature Neuroscience, 2010, 13(12): 1451-1453.

DOI：10.1038/nn.2695

There is a longstanding controversy on the identity of synaptic vesicles undergoing spontaneous versus evoked release. A recent study, introducing a new genetic probe, suggested that spontaneous release is driven by a resting pool of synaptic vesicles refractory to stimulation. We found that cross-depletion of spontaneously or actively recycling synaptic vesicle pools occurred on stimulation in rat hippocampal neurons and identified the recycling pool as a major source of spontaneous release.

• 出版日期2010-12
• 单位河北医科大学