Monitoring Doppler patterns and clinical parameters may predict feeding tolerance in intrauterine growth-restricted infants

作者：Bozzetti Valentina^*; Paterlini Giuseppe; Gazzolo Diego; Van Bel Frank; Visser Gerard H A; Roncaglia Nadia; Tagliabue Paolo E

来源：Acta Paediatrica, 2013, 102(11): E519-E523.

DOI：10.1111/apa.12380

• Doppler velocimetry
• Feeding tolerance
• Full enteral feeding
• Intrauterine growth restriction
• Minimal enteral feeding

AimTo detect predictors of feeding tolerance in intrauterine growth restriction (IUGR) infants with or without brain-sparing effect (BS). %26lt;br%26gt;MethodsWe conducted a case-control study in 70 IUGR infants (35 IUGR with BS, matched for gestational age with 35 IUGR infants with no BS). BS was classified as pulsatility index (PI) ratio [umbilical artery (UAPI) to middle cerebral artery (MCAPI) (U/C ratio)] %26gt; 1. Clinical parameters of feeding tolerance - days to achieve full enteral feeding (FEF) - were compared between the IUGR with BS and IUGR without BS infants. Age at the start of minimal enteral feeding (MEF) was analysed. %26lt;br%26gt;ResultsAchievement of FEF was significantly shorter in IUGR infants without BS than in IUGR with BS. IUGR with BS started MEF later than IUGR without BS infants. Significant correlation of MEF and FEF with UA PI, U/C ratio and CRIB score was found. Multiple linear regression analysis showed significant correlations with CRIB score and caffeine administration (MEF only), and sepsis (FEF only) and U/C ratio (for both). %26lt;br%26gt;ConclusionImpaired gut function can be early detected by monitoring Doppler patterns and clinical parameters.

• 出版日期2013-11