Nephrotoxicity of Acetamiprid on Male Mice and the Rescue Role of Vitamin E

作者：Zhang Jiao Jiao; Wang Yi; Xiang Hai Yang; Jia Hua; Zhang; Wang Xian Zhong^*

来源：Journal of Animal and Veterinary Advances, 2012, 11(15): 2721-2726.

DOI：10.3923/javaa.2012.2721.2726

• Acetamiprid
• nephrotoxicity
• vitamin E
• oxidative stress
• tubules
• kidney

Acetamiprid has a wide range of effect on physiological functions in mammals. The objective of this study was to examine the effect of acetamiprid on kidney of male mice and to study the ameliorative role of antioxidant on the nephrotoxicity of acetamiprid. Fifty adult Kunmin male mice (25-30 g) were divided into five groups (n = 10 per group): controls, blanks, acetamiprid alone, acetamiprid and vitamin E and E alone. All groups were treated for 35 days. The results showed that acetamiprid significantly increased the activity of urea, Cr and the concentration of P and decreased the concentrations of UA and Ca. The mice treated with acetamiprid had damaged renal corpuscles and tubules based on the histological structure of kidney. Furthermore, the acetamiprid residue in kidneys was lower than that in livers which suggests that renal function may be affected through the indirect action of acetamiprid metabolites. Vitamin E significantly ameliorated the effects of acetamiprid. Researchers conclude that acetamiprid could damage kidney which may be include by the oxidative stress of acetamiprid metabolites. As an antioxidant, vitamin E can reduce the nephrotoxicity of acetamiprid.

• 出版日期2012
• 单位西南大学