Downregulated miR-187 contributes to the keratinocytes hyperproliferation in psoriasis

作者：Tang, Lipeng; He, Songmin; Zhu, Ying; Feng, Bing; Su, Zuqing; Liu, Bo; Xu, Fangfang; Wang, Xieqi; Liu, Hongying; Li, Chutian; Zhao, Jie; Zheng, Xirun; Li, Caiyun; Sun, Chaoyue; Lu, Chuanjian^*; Zheng, Guangjuan^*

来源：Journal of Cellular Physiology, 2019, 234(4): 3661-3674.

DOI：10.1002/jcp.27135

• CD276
• epidermal hyperplasia
• keratinocytes hyperproliferation
• microRNA-187 (miR-187)
• psoriasis

Psoriasis is a common chronic skin disease characterized by epidermal hyperplasia and inflammation. However, the pathogenesis of psoriasis is multifactorial and is not fully understood. MicroRNAs (miRNAs) represent a promising class of small, noncoding RNA molecules that have a large impact on cellular functions by regulating gene expression. Here we reported that microRNA-187 (miR-187), which is one of the most dynamic microRNAs identified in the deep screening miRNAs profile, is downregulated in inflammatory cytokines-stimulated keratinocytes and psoriatic skins. By luciferase activity assay and gain-of-function studies, we showed that miR-187 inhibits keratinocytes hyperproliferation by targeting CD276. Moreover, overexpression of miR-187 decreases acanthosis and reduces the disease severity in psoriasis mouse models. Taken together, the results of our study implies miR-187 as a critical factor in psoriasis pathogenesis, which could be a potent target for psoriasis treatment.

• 出版日期2019-4
• 单位广州中医药大学