Autoantibodies in Patients with Fasciolosis

作者：S Kaya; M Demirci; E Sesli etin; B Ciciolu Aridoan

来源：Iranian Journal of Parasitology, 2009.

• Fasciolosis
• Autoantibody
• Autoimmunity

%26quot;nBackground: Antiself humoral immune responses have been detected not only in classical autoimmune dis-eases, but autoantibodies have also been found in sera of patients suffering from chronic parasitic dis-eases. We aimed to investigate the role of fasciolosis as a trigger factor of autoimmune reactivity by searching some anti-bodies related to hepatobiliary systems, in patients with fasciolosis. %26quot;nMethods: Thirty-two patients (17 males, 15 females) with fasciolosis were included in this case-control study. Anti-nuclear antibodies (ANA) Screen (antigen mixture of dsDNA, histones, nRNP/Sm, Sm, SS-A, SS-B, Scl-70, Jo-1, ribosomal P-proteins, centromere) ELISA and single-antigen ELISAs for detection of some antibodies (dsDNA, Anti-M2, Anti- liver-kidney microsomes type 1 (LKM-1) and Myeloperoxidase (MPO) were carried out. %26quot;nResults: ANA-screen, M-2, LKM-1, MPO and anti-dsDNA positivity were detected with ELISA in 7, 7, 4, 2 and 2 of 32 patients with fasciolosis, consecutively. No statistically significant difference was de-tected for any of the autoantibodies%26apos; frequency between patients with fasciolosis and control group. How-ever, autoantibody positivity rate was significantly higher in patients with fasciolosis (50 %) than control group (12.5 %). Absorbance values of all autoantibodies in patients with fasciolosis were statistically sig-nificant higher than controls. %26quot;nConclusion: These results lent support to the role of fasciolosis as a trigger factor of autoimmune reactiv-ity by the breakdown of tolerance. In spite of the extensive knowledge that has accumulated, the specific relationship be-tween fasciolosis and autoimmunity is still obscure.

• 出版日期2009