A new combined therapy for functional organ preservation and survival in lateral oropharyngeal wall cancer

作者：Furusaka Tohru^*; Matsuda Akira; Tanaka Akane; Matsuda Hiroshi; Asakawa Takeshi; Shigihara Shuntaro

来源：Acta Oto-Laryngologica, 2014, 134(8): 872-880.

DOI：10.3109/00016489.2014.899709

• Head and neck cancer
• squamous cell carcinoma
• neoadjuvant chemotherapy
• concurrent chemoradiation therapy
• neck dissection

Conclusion: The outcome of this treatment was good, indicating that it is safe and effective. A favorable outcome was obtained, especially in patients with T3, N0-1, and N2a-b cancer, while outcome remained unfavorable in patients with T4a and N2c cancer. Consideration should be given to the need for intensity-modulated radiation therapy (IMRT) and maintenance therapy. Objective: To improve the survival and functional organ preservation rates in patients with lateral oropharyngeal squamous cell carcinoma. Methods: The primary site was treated conservatively by neoadjuvant chemotherapy and/or concurrent chemoradiation therapy. Chemotherapy was administered by superselective intra-arterial infusion and cervical lymph node metastasis was treated by radical neck dissection. Results: Among 71 patients, the 5- and 10-year overall survival rates were 85.1% and 63.5%, respectively; and the 5- and 10-year functional organ preservation rates were 61.0% and 51.6%, respectively. The outcomes were especially good in patients with T3 N0-1, and N2a-b cancer. All patients with N2c cancer had poor outcomes.

• 出版日期2014-8