Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis

作者：Zhang, Jun; Li, Shuang; Hu, Shuqiong; Yu, Jiguo; Xiang, Yi^*

来源：BMC Ophthalmology, 2018, 18(1): 274.

DOI：10.1186/s12886-018-0945-5

• Age-related macular degeneration
• C3 gene
• Polymorphism
• Meta-analysis

BackgroundThe purpose of this study is to discuss whether genetic variants (rs2230199, rs1047286, rs2230205, and rs2250656) in the C3 gene account for a significant risk of advanced AMD.MethodsWe performed a meta-analysis using electronic databases to search relevant articles. A total of 40 case-control studies from 38 available articles (20,673 cases and 20,025 controls) were included in our study.ResultsIn our meta-analysis, the pooled results showed that the carriage of G allele for rs2230199 and the T allele for rs1047286 had a tendency to the risk of advanced AMD (OR=1.49, 95% CI=1.39-1.59, P<0.001; OR=1.45, 95% CI=1.37-1.54, P<0.001). Moreover, in the subgroup analysis based on ethnicity, rs2230199 and rs1047286 polymorphisms were more likely to be a predictor of response for Caucasian region (OR=1.48, 95% CI=1.38-1.59, P<0.001; OR=1.45, 95% CI=1.37-1.54, P<0.001). Besides, pooled results suggested that the G allele of rs2230199 could confer susceptibility to advanced AMD in Middle East (OR=1.62, 95% CI=1.33-1.97, P<0.001).ConclusionIn our meta-analysis, C3 genetic polymorphisms unveiled a positive effect on the risk of advanced AMD, especially in Caucasians. Furthermore, numerous well-designed studies with large sample-size are required to validate this conclusion.

• 出版日期2018-10-23
• 单位华中科技大学; 武汉市中心医院