Diluted hydrochloric acid generates larger radiofrequency ablation lesions in excised porcine livers

作者：Luo, Rong-Guang; Fao, Fei; Huang, Jin-Hua^*; Gu, Yang-Kui; Jiang, Xiong-Ying; Huang, Ying-Jie

来源：Diagnostic and Interventional Radiology, 2013, 19(2): 145-149.

DOI：10.4261/1305-3825.DIR.6093-12.1

• SMALL HEPATOCELLULAR-CARCINOMA
• PERCUTANEOUS ETHANOL INJECTION
• MICROWAVE COAGULATION THERAPY
• INTERNALLY COOLED ELECTRODES
• RANDOMIZED CONTROLLED-TRIAL
• EX-VIVO EVALUATION
• THERMAL ABLATION
• TUMOR ABLATION
• WET ELECTRODE
• MODEL

PURPOSE @@@ This study evaluated the influence of continuous infusion of diluted hydrochloric acid during radiofrequency ablation (RFA) on the size of ablated lesions. @@@ MATERIALS AND METHODS @@@ Experiments were performed in 20 excised porcine livers using three different treatment modalities: (1) normal saline-enhanced RFA (NS-RFA), which was normal saline pumped into ablated tissue during RFA; (2) diluted hydrochloric acid ablation (DHAA), which was 3 mol/L diluted hydrochloric acid (HCl) injected into hepatic tissue without RFA; and (3) HCl-enhanced RFA (HCl-RFA), which was 3 mol/L diluted HCl continuously infused into ablated tissue during RFA. We produced 20 HCl-RFA and NS-RFA lesions, respectively, using a monopolar perfusion electrode connected to a commercially available radiofrequency generator, and 20 DHAA lesions using an 18-gauge Chiba needle. The ablated lesions were evaluated both macroscopically and histologically. Dimensions of lesions were compared among HCl-RFA, NS-RFA, and DHAA. @@@ RESULTS @@@ The ablated lesions had an elliptical-like shape and were well-demarcated with normal liver tissue. The mean volume, longitudinal diameter, and transverse diameter of NS-RFA lesions were 11.24 +/- 0.29 cm(3), 3.49 +/- 0.07 cm, and 2.48 +/- 0.03 cm, those of HCl-RFA lesions were 58.14 +/- 3.05 cm(3), 5.51 +/- 0.05 cm, and 4.49 +/- 0.11 cm, and those of DHAA lesions were 4.41 +/- 0.16 cm(3), 2.43 +/- 0.08 cm, and 1.8 +/- 0.03 cm, respectively. The mean dimensions of HCl-RFA lesions were the largest among the three types of ablation (P<0.001). @@@ CONCLUSION @@@ Under the present experimental conditions, the continuous infusion of diluted HCl during RFA can generate larger ablated lesions than NS-RFA or DHAA in excised porcine livers.

• 出版日期2013-3
• 单位南昌大学; 中山大学