Association between vitamin D and Apo B concentrations in Argentinean Indian children

作者：Hirschler Valeria^*; Maccallini Gustavo; Molinari Claudia; Ines Urrutia; Castano Luis A; Sanchez Milva; Colque Graciela; Aranda Claudio; Hidalgo Mariana; Urzagasti Mirta

来源：Clinica Chimica Acta, 2014, 429: 147-151.

DOI：10.1016/j.cca.2013.12.012

• Non-traditional markers
• Cardiovascular disease
• Apo B
• Indian children
• Vitamin D

Objective: The objective of the study was to determine the prevalence of vitamin D insufficiency and its association with non-traditional cardiovascular disease (CVD) risk factors such as Apo B in South American Indian school children. %26lt;br%26gt;Methods: A cross-sectional study of 355 children (166 Males) aged 9.6 +/- 23 y was performed. Anthropometric measures, glucose, lipids, insulin, Apo B, Apo A, and vitamin D concentrations were measured. %26lt;br%26gt;Results: The prevalence of overweight and obesity was 10.7% (38) per CDC. One child (0.3%) had optimal vitamin D concentrations [25(OH)D[%26gt;30 ng/ml. Univariate analysis showed significant associations between vitamin D and HDL-C (r = 0.12 p %26lt; 0.05), age (r = -0.11 p %26lt; 0.05) BMI (r = -0.22 p %26lt; 0.05), LDL-C (r = -0.22 p %26lt; 0.01), triglycerides (r = -0.16 p %26lt; 0.01), non HDL-C (r = 0.21 p %26lt; 0.01), Apo B (r = -0.23 p %26lt; 0.01), Apo B/Apo A (r = -0.21 p %26lt; 0.01), insulin (r = -0.17 p %26lt; 0.05), and HOMA-IR (r = -0.16 p %26lt; 0.05). Multiple linear regression analysis showed that female gender and Apo B were significantly associated with vitamin D adjusted for confounding factors (R-2 0.12). %26lt;br%26gt;Conclusion: Vitamin D deficiency was associated with increased Apo B among Indian children, suggesting that it could be used as a risk marker of CVD.

• 出版日期2014-2-15