Neoglycoenzyme-Gated Mesoporous Silica Nanoparticles: Toward the Design of Nanodevices for Pulsatile Programmed Sequential Delivery

作者：Diez Paula; Sanchez Alfredo; de la Torre Cristina; Gamella Maria; Martinez Ruiz Paloma; Aznar Elena; Martinez Manez Ramon^*; Pingarron Jose M^*; Villalonga Reynaldo^*

来源：ACS Applied Materials & Interfaces, 2016, 8(12): 7657-7665.

DOI：10.1021/acsami.5b12645

• enzymes
• mesoporous silica
• delivery
• nanoparticles
• esterase
• neoglycoenzyme
• glucose

We report herein the design of a stimulus-programmed pulsatile delivery system for sequential cargo release based on the use of a lactose-modified esterase as a capping agent in phenylboronic acid functionalized mesoporous silica nanoparticles. The dual-release Mechanism was based on the distinct stability of the cyclic boronic acid esters formed with lactose residues and the long naturally Occurring glycosylation chains in the modified neoglycoenzyme. Cargo delivery in succession was achieved using glucose and ethyl butyrate as triggers.

• 出版日期2016-3-30