A Smart and Efficient One-Pot Green Synthesis of Novel 1, 2, 3-Triazolyl Pyrazoline-/Indazolyl-Carbothioamide Hybrids under Solvent-Free Grinding Strategy at Room Temperature

作者:Ranganathan, Raja; Archana, Sivasubramaniyan; Dinesh, Murugan; Jaabil, George; Nagarajan, Sangaraiah; Ponnuswamy, Alagusundaram*; Saranya, Kanagarajan; Murugavel, Saminathan
来源:ChemistrySelect, 2018, 3(35): 10091-10095.
DOI:10.1002/slct.201802346

摘要

A smart and straightforward route has been developed for the green synthesis of novel 1,2,3-triazolyl pyrazoline-/indazolyl-carbothioamide hybrids from easily accessible starting materials for the first time via one-pot sequential four component reaction under solvent-free grinding protocol at room temperature. Notably, this protocol is meritorious in the sense that it is inexpensive, expeditious, devoid of tedious separation methods, environmentally benign and it involves mild reaction conditions affording good to excellent yields (84-97%) of the products.