Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy

作者：Soares Michael J^*; Chakraborty Damayanti; Kubota Kaiyu; Renaud Stephen J; Rumi M A Karim

来源：International Journal of Developmental Biology, 2014, 58(2-4): 247-259.

DOI：10.1387/ijdb.140083ms

• hemochorial placentation
• natural killer cell
• trophoblast
• PI3K/AKT
• FOSL1
• hypoxia
• NOTCH
• STOX1

Implantation of the embryo into the uterus triggers the initiation of hemochorial placentation. The hemochorial placenta facilitates the acquisition of maternal resources required for embryo/fetal growth. Uterine spiral arteries form the nutrient supply line for the placenta and fetus. This vascular conduit undergoes gestation stage-specific remodeling directed by maternal natural killer cells and embryo-derived invasive trophoblast lineages. The placentation site, including remodeling of the uterine spiral arteries, is shaped by environmental challenges. In this review, we discuss the cellular participants controlling pregnancy-dependent uterine spiral artery remodeling and mechanisms responsible for their development and function.

• 出版日期2014