科研之友
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摘要
A highly active and enantioselective phosphine-nickel catalyst for the asymmetric hydrogenation of alpha,beta-unsaturated esters has been discovered. The coordination chemistry and catalytic behavior of nickel halide, acetate, and mixed halide-acetate with chiral bidentate phosphines have been explored and deuterium labeling studies, the method of continuous variation, nonlinear studies, and kinetic measurements have provided mechanistic understanding. Activation of molecular hydrogen by a trimeric (Me-DuPhos)(3)Ni-3(OAc)(5)I complex was established as turnover limiting followed by rapid conjugate addition of a nickel hydride and nonselective protonation to release the substrate. In addition to reaction discovery and optimization, the previously unreported utility high throughput experimentation for mechanistic elucidation is also described.
- 出版日期2016-3-16
